This section covers the ingredients found in Inflame & Pain Relief™ and discusses WHY & HOW they work, including links to clinical studies.

Below you'll find "Supplement Facts". You can also see "recommended use" instructions and "Ingredient Summaries".

Supplement Facts
Serving Size: 4 Capsules
30 Day Supply

Ingredients Amount Per Serving %DV*

IPR Synergy Optimizer™ Blend 3000 MG
Turmeric/Curcumin (95% Extract, Tetrahydrocurcuminoids)
(Blend of Curcumin C3 Complex® / C3 Reduct® / BCM-95® Bio-Curcumin®)
800 MG  
Ginger Extract (Orgainc; 5% gingerols) 200 MG  
AprèsFlex® Boswellia Serrata (65% extract) 240 MG  
Green Tea Extract (Theaflavin) (98% poly, 50% EGCG) 400 MG  
White Willow Bark (salicin) 25% salicylic acid 200 MG  
Pine Bark Extract (Pinus massoniana) [97% Proanthocyanidins] 200 MG  
Astragin® Astragalus 100 MG  
Trans-Resveratrol (50% Extract; Japanese knotweed) 280 MG  
Uncaria Tomentosa (cat's claw; 10:1 concentration; 2.3% pentacyclic oxindole alkaloids) 100 MG  
Quercetin Phytosome 200 MG  
PARACTIN® Andrographis 10:1 280 MG  

† Daily Value not established
* Percent Daily Values are based on a 2,000 calorie diet.
Made in USA Gluten free Vegetarian Non GMO Additive and filler free

Ingredient Summaries

The Inflame & Pain Relief™ formula works so well and is popular because of the specific ingredients used in the correct combinations, dosages and extracts; resulting in maximum results & benefits. Click the ingredients below and a detailed description will appear under it.

Intro Summary: Curcumin extract is extremely potent at promoting healthy inflammation levels and numerous health benefits.* We've utilized 3 specific, patented forms for maximum absorbability, bioavailability & effectiveness to ensure maximum results.

Curcumin is the amazing active compound that is found within the turmeric root. It may be one of the most unique nutritional supplements in existence, IF you take the correct, absorbable form (more on that in a minute).

My Top 5 Curcumin Benefits

  1. Supports Healthy Inflammatory Response:* Scientists now believe that chronic, low-level inflammation plays a major role in most health ailments, from head to toe. Your mind, heart, joints, muscles, eyes, lungs, skin, hair, etc.1-6*
  2. Powerful Antioxidant: It helps neutralize free radical damage, that may accelerate aging.7* Additionally, it also helps boost the body's own antioxidant enzymes.8*
  3. Supports Healthy Brain Function: It helps increase brain-derived neurotrophic factor (BDNF), which helps preserver youthful brain function..9,10,14*
  4. Supports Heart Health: Curcumin's benefits has been shown to help lower the risk of heart problems associated with inflammation.11-13*
  5. Healthy Immune Function: Helps support healthy immune system response & function.15,16*

WARNING - The Major Problem With Curcumin

As great as these benefits are, the biggest problem with Turmeric/Curcumin is that it's poorly absorbed.

Which means, if you don't utilize the correct form and dose, you won't get the positive benefits and you'll just be wasting time and money.

Almost all Curcumin extracts (even those with a minimum 95% extract) are only 50% absorbed. So you'll have to take more than double the amount to get the optimal benefits.

3 Most Potent, Highest Absorbable &
Scientifically Validated Forms Of Curcumin

This is why we've utilized the 3 most potent and highest absorbable Curcumin extracts - Patented & Scientifically Proven.

Curcumin C3 Reduct® (standardized min 95% tetra-hydro curcuminoids ) - One of the most active forms of Curcumin with 95% tetra-hydro curcuminoids, which is pre-converted and goes to work immediately.

Curcumin C3 Complex® (standardized min 95% total curcuminoids) - Is a patented and scientifically evaluated “Bioprotectant” composition of three Curcuminoids [Curcumin, Demethoxycurcumin (DMC) and Bisdemethoxycurcumin (BDMC)]. It's the most studied and validated Curcumin extract on the market. This is more of a slow-release form, over 12 hours.

BCM-95® Bio-Curcumin® - Is validated to have a 97% absorption rate and almost 9x higher bioavailability in the blood.. The end result is higher blood concentrations, in less time. Thus, the positive effects are felt faster at an even lower dose, extended over 8 hours.

NOTE: Two things to remember here:

  1. You want to make sure that you ONLY use the highest extract of min 95% because Curcumin isn't absorbed well.
  2. Use only the scientifically researched, most highly absorbable forms which is a combination of Curcumin C3 Reduct®, Curcumin C3 Complex® and BCM-95® Bio-Curcumin®

Ginger contains numerous beneficial compounds, including gingerols, which have free-radical scavenging and healthy inflammatory supporting properties.17*

Equestriennes contribute to dangerous inflammatory reactions. Specific compounds in ginger have been found to help inhibit enzymes that produce leukotrienes.18,19*

Ginger also works to help support a healthy inflammatory response by affecting several other compounds and cellular pathways, by promoting healthy & youthful levels of*:

  1. Inflammatory mediators, such as tumor necrosis factor-alpha, C-reactive protein, interleukin-1b and interleukin-6.20-22*
  2. Nuclear factor kappa B (NF-kB) pathways, which are involved in the initiation of chronic inflammation.20-22*

INTRO: As with most ingredients, absorbability is a major issue. Unfortunately, most ginger is heat processed using high-heat methods, which destroys almost all the benefits.

However, Inflame & Pain Relief™ Ginger is naturally dried and not subjected to additional heat. This process ensures the presence of active compounds that are beneficial to the gastrointestinal tract, resulting in maximum benefits.

One of the problems with aging is higher levels of 5-LOX. 5-lipoxygenase (5-LOX) is a member of the lipoxygenase family of enzymes. Excess levels of the enzyme 5-LOX cause negative inflammatory responses that have been linked to common effects in aging individuals (such as pain).*

Unfortunately, the typical diet most people eat these days, causes an over production of the 5-LOX enzyme. This further increases pro-inflammatory compounds, which attacks the:

  • joints (& soft tissue)
  • arterial walls (poor blood flow)
  • skin (wrinkles)
  • hair (balding)
  • and other tissue

Used for centuries to help promote healthy inflammatory factors, Boswellia supports and acts as a natural 5-LOX reducer, intervening at the cellular level to minimize its unwanted negative effects.*

Clinical studies reveal that a compound contained in Boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid)23,24 may be the key to its beneficial action.*

INTRO: The problem is that Boswellia is poorly absorbed into the blood.25 Because of this, Inflame & Pain Relief™ utilizes a patented, standardized form of Boswellia called AprèsFlex®. AprèsFlex® absorbs into the blood 52% more than other forms of Boswellia extracts.25*

Green tea extract has numerous health benefits, one of them being a powerful healthy response to inflammation due to the Theaflavin, polyphenols & EGCG.*

White willow bark is known as "nature's aspirin" and has been used for centuries to help support healthy pain relief, discomfort & response to inflammation.6* The active ingredient that causes the benefits of willow bark is salicin.

Inflame & Pain Relief™ uses the highest extract, at 25% salicylic acid. This means a lower dose is required, but resulting in more positive benefits.*

Intro Summary: One of the primary ways Pine bark extract helps with inflammation, is by supporting the reduction of inflammatory cytokine molecules.*

Pine bark extract has numerous health benefits by supporting healthy:

  • response to inflammation & histamine*
  • blood flow and circulation by strengthening the walls of your blood vessels and capillaries*
  • joint flexibility & mobility*

Joint Pain & Inflammation

The cushioning cartilage in your joints become damaged through aging + wear and tear, which can cause inflammation and pain.* This can happen even faster for those that exercise.

Pine bark extract can ease these symptoms by:

  • supporting healthy inflammatory response*
  • promoting mobility + flexibility of joints*
  • helping reduce aches + pains*

NOTE: This is one of my favorite supplements because it has so many health benefits. The minimum daily dose for joint health and inflammation health is 100 mg, with the correct optimal dose being 200 mg daily -- which is the exact dose in Inflame & Pain Relief™.

It's also important to point out that we use a 97% extract. Most companies use "dead" root or 50% or less. Thus, with Inflame & Pain Relief™ you're getting the optimal dose at the best value!

Astragin® is a patented form of Astragalus, with over 25+ clinical studies. Astragalus is from one of the most powerful immune-building plants on the planet.*

It's an "adaptogen", which means it activates when you're under stress to help promote healthy cortisol levels & inflammatory response.* Additionally, it helps increase the absorption of other nutrients by 92%. 32

Astragalus works by suppressing NF-kB and AP-1 signaling pathways, which is linked to unhealthy inflammation.*

Intro Summary: Works by supporting healthy inflammatory markers and enzymes.* The "trans" form at 50% extract is the most potent and absorbable form.

Best known as a compound found in red grapes and red wine, resveratrol helps support and maintain optimal health and longevity.34*

Inflame & Pain Relief™ contains trans-resveratrol, the form most abundant in red wine, which is well-absorbed and stable.35,36 Daily use of can help:

  • promotes healthy insulin sensitivity*
  • encourages enhanced mitochondrial function*
  • supports a healthy inflammatory response*
  • demonstrated beneficial cardiovascular activity.37-39*

Inflammatory Processes

Aside from its indirect antioxidant effects on inflammation, resveratrol also affects very specific inflammatory processes.*

For one, it can help support healthy levels of inflammatory COX enzymes, which are also the main target of commonly used painkillers and anti-inflammatory drugs.40*

However, its effects run much deeper than these conventionally targeted enzymes. Resveratrol also helps support numerous inflammatory responses:*

  • NF-kB pathway, one of the most important and deeply rooted triggers of inflammation in the body.41*
  • HMGB1, a protein made by immune cells that can cause inflammation and tissue damage.42*
  • STAT3, which contributes to problems in most people with constant inflammation.43*

NOTE: Numerous studies have shown that combining Resveratrol with Quercetin, creates a special synergy - improving absorption & enhancing healthy inflammatory benefits.43-45* Which is why we've also added Quercetin into the formula (see below).

Quercetin is a bioflavonoid that supports healthy immune function and inflammatory response.46,47*

One of the primary ways quercetin works, is by helping support important inflammatory substances and pathways (including COX-2 and CRP), similar to drugs (but without the negatives).*

It also helps support healthy prostaglandins, one of the key mediators of the inflammatory response.48,49*

NOTE: Inflame & Pain Relief™ provides quercetin encased in a plant-derived phytosome delivery system, which makes absorption easier. The quercetin in our formula is up to 50 times more bioavailable than a dose of standard quercetin found in most supplements.46,47 *

Cat’s claw is rich in three major groups of chemical compounds: alkaloids, terpenoids, and flavonoids. It works by supporting healthy & youthful:

  • Inflammatory molecules TNF-α and NF-κB.50-52*
  • Release of iNos, an enzyme that creates free radicals as part of the immune response, which can lead to inflammation.53*
  • Release of COX-1 and COX-2, enzymes that can play crucial roles in inflammation and pain.54,55*

ParActin™ is a patented standardized natural extract of Andrographis Paniculata, scientifically shown to help promote healthy inflammatory response and support healthy brain and joint function by naturally invigorating the PPAR gamma receptor, which are cytokines linked to pain and redness from everyday activities.*

We've used a patented blend of these andrographolides because they've been scientifically shown to work in humans.60-62*

References: